Sustainable Chemical Syntheses

Our modular platform for a sustainable process design in fine chemicals synthesis

At Fraunhofer IMM, we develop sustainable solutions for our customers in the chemical, pharmaceutical and biotechnological sectors. We have developed a modular platform technology that enables us and our customers to produce high-quality fine chemicals using classical thermal synthesis, photochemistry and electro organic synthesis on different scales. We support our customers from the first discussion about their desired process via feasibility studies including all experimental and analytical data for decision-making to the final product. This is how we accelerate the successful implementation of innovative and sustainable ideas and wishes of our customers in a professional and personal environment at our institute.
Our approach is based on decades of experience in micro process engineering and continuous flow chemistry. Our engineers design flow reactors according to customer requirements and integrate them into synthesis plants for the screening of process parameters. High-performance light sources based on commercially available high-performance LEDs or surface and structure optimized electrodes are developed in our institute for their application in photochemistry and electrochemistry. In addition to our own laboratory for the production of inorganic catalysts, we can also draw on the extensive Fraunhofer network and, in close cooperation with our colleagues from other institutes, we can offer customized enzymes for biocatalysis in our reactors. Of course, we round off our customer offering with comprehensive chemical analysis so that the desire for a more sustainable synthesis of fine chemicals can be evaluated based on reliable experimental and analytical data.

NCS modules
© Fraunhofer IMM

Our research institute is your one-stop shop for sustainably designed fine chemical syntheses. With our empirical consulting, you save on personnel and investment costs, because we have the right scientists, equipment and know-how to thoroughly test your idea and turn it into a fully-fledged product. We support you as a partner in a joint project to find a solution to your challenge in terms of resources, costs and sustainability.

 

Photoreactors & plants

Offer to our customers

Research & Development Services

  • Process parameter screening in batch and continuous flow
  • Feasibility study for the transfer from batch to continuous flow
  • Process development including reactor and plant realization
  • Method development for a comprehensive chemical analysis
  • Sample analysis, method and protocol assistance and scientific advice

 

Core Competencies

  • Thermal chemistry including metal and organo catalysis
  • Photochemistry with focus on photocatalysis applying visible light
  • Electro-organic synthesis
  • Biocatalysis with enzymes in cooperation with Fraunhofer IME
  • Sample analysis including the establishment of methods and protocols, as well as scientific advice

 

Instrumentation Facility

  • Specialized continuous flow reactors and lab plants:
    • Customer-specific mixers and reactors for thermal chemistry
    • Photochemistry
    • Electro-organic synthesis
  • Gas chromatography: 
    • Nexis GC-2030
    • GC-3900
  • Gas chromatography - mass spectrometry:
    • GCMS-QP2010 Ultra
  • Liquid chromatography - mass spectrometry:
    • 1260 Infinity II / 6530 Q-TOF
  • High performance liquid chromatography:
    • Prominence 20A series setup with autosampler
    • VP 10A series setup with manual injection
  • Ion chromatography:
    • ICS-1100 RFIC
  • Nuclear magnetic resonance spectroscopy:
    • Spinsolve 80 ULTRA Multi X with autosampler
    • Spinsolve 80 ULTRA Carbon as mobile NMR platform for inline analysis
  • UV-Vis:
    • Lambda 1015
    • AVASPEC ULS2048CL for inline analysis
  • Infrared spectroscopy:
    • React IR 15 for inline analysis
    • Magna-IR 750

Selected Publications

Continuous Flow Chemistry

T. H. Rehm, C. Berguerand, S. Ek, R. Zapf, P. Löb, L. Nikoshvili, L. Kiwi-Minsker
Continuously operated falling film microreactor for selective hydrogenation of carbon-carbon triple bonds.
Chem. Eng. J., 2016, 293, 345

T. H. Rehm, D. Reinhard, H.-J. Kost, C. Hofmann, R. Zapf, P. Löb, Y. Laribi, P. Perrichon, C. Berguerand, L. Kiwi-Minsker, E. Sulman, G. Szirbik, H. Richert, J. Lang, M. Gottfried, S. Roggan
Chemoselective three-phase hydrogenation of an Ombrabulin nitro-stilbene intermediate in a continuous-flow mobile platform.
Chem. Eng. J., 2017, 316, 1069

E. Cermjani, C. Deckers, M. Maskos, T. H. Rehm
Selective decarboxylative fluorination of β-keto acids in aqueous media: 19F-NMR-assisted batch optimization and transfer to continuous flow.
Chem. Eur. J., 2024, 31, e202404435

 

Photochemistry

T. H. Rehm, S. Gros, P. Löb, A. Renken
Photonic contacting of gas-liquid phases in a falling film microreactor for photocatalysis with visible light.
React. Chem. Eng., 2016, 1, 636

D. Fabry, Y. A. Ho, R. Zapf, W. Tremel, M. Panthöfer, M. Rueping, T. H. Rehm
Blue light mediated C-H arylation of heteroarenes with TiO2 as immobilized photocatalyst in a continuous-flow microreactor.
Green Chem., 2017, 19, 1911

C. Deckers, T. H. Rehm
In situ diazonium salt formation and photochemical aryl-aryl coupling in continuous flow monitored by inline NMR spectroscopy
Chem. Eur. J., 2024, e202303692

B. Herbig, E. Cermjani, D. Hanselmann, A. Schmitt, C. Deckers, T. H. Rehm, K. Mandel, S. Wintzheimer
Hydrogen peroxide producing titania-silica supraparticles as tailored photocatalysts for flow chemistry reactions in microfluidic reactors.
Chem Bio Eng., 2025, 2, 199

 

Electroorganic synthesis

A. Ziogas, C. Hofmann, S. Baranyai, P. Löb, G. Kolb
Novel Flexible Electrochemical Microreactor and its Validation by Three Model Electrosyntheses.
CIT, 2020, 92, 513

A. Ziogas, J. Belda, H.-J. Kost, J. Magomajew, R. Sperling, P. Wernig
Peroxodicarbonate: Electrosynthesis and first directions to green industrial applications.
Curr. Res. Green Sustain. Chem. 2022, 5, 2666.

N. Baumgarten, B. Etzold, P. Löb, J. Magomajew, A. Ziogas
Continuous Kolbe Electrolysis Using an Electrochemical Microreactor, Product Separation, and Electrolyte Recycling.
CIT, 2024, 96, 789

J.  Fabarius, C. Pietzka, D. Pangotra, B. Wriedt, L. Vieira, C. Sagstetter, M. Speck, A. Ziogas, N. Baumgarten, H.-J. Kost, P. Löb, K. Patzsch, C. Bernau, S. Boeringer, D. Pico, A. Lieske, M. Vater, U. Wendler, A. Roth
Process Cascade for the Production of Green Polymers from CO2 and Electric Energy.
CIT, 2024, 96, 698

 

Miscellaneous

T. H. Rehm
Photochemistry in flow for drug discovery.
in Flow chemistry in drug discovery; Eds: J. Alcázar, A. de la Hoz Ayuso, Á. Díaz Ortiz; Springer, Berlin, Heidelberg, 2021

T. H. Rehm, U. Scholz
Durchflusschemie eröffnet neue Wege.
CHEManager, 2023, 5, 10

 

We invite you to get to know us and our expertise in solving your problems. We offer you a first impression of our research and development work in an online meeting or during a visit to our facilities in Mainz-Hechtsheim, Germany. You are also welcome to use our Rent-a-Scientist offer to carry out initial experiments on your idea in our laboratory together with us.

 

For inquiries and collaborations, please contact us.
For more information, follow us on our Division Chemistry showcase page on LinkedIn.