Sustainable Chemical Syntheses

Our research institute is your one-stop shop for sustainably designed fine chemical syntheses. With our empirical consulting, you save on personnel and investment costs, because we have the right scientists, equipment and know-how to thoroughly test your idea and turn it into a fully-fledged product. We support you as a partner in a joint project to find a solution to your challenge in terms of resources, costs and sustainability.

Photoreactors & plants

Continuous flow reactors for electrochemistry

Research & Development Services

• Process parameter screening in batch and continuous flow
• Feasibility study for the transfer from batch to continuous flow
• Process development including reactor and plant realization
• Method development for a comprehensive chemical analysis
• Sample analysis, method and protocol assistance and scientific advice

Core Competencies

• Thermal chemistry including metal and organo catalysis
• Photochemistry with focus on photocatalysis applying visible light
• Electro-organic synthesis
• Biocatalysis with enzymes in cooperation with Fraunhofer IME
• Sample analysis including the establishment of methods and protocols, as well as scientific advice

Instrumentation Facility

• Specialized continuous flow reactors and lab plants:
  • Customer-specific mixers and reactors for thermal chemistry
  • Photochemistry
  • Electro-organic synthesis
• Gas chromatography for chiral analysis: 
  • Nexis GC-2030
  • GC-3900
• Gas chromatography - mass spectrometry:
  • GCMS-QP2010 Ultra
• Liquid chromatography - mass spectrometry:
  • 1260 Infinity II / 6530 Q-TOF
• High performance liquid chromatography for chiral analysis:
  • Prominence 20A series setup with autosampler
  • VP 10A series setup with manual injection
• Ion chromatography:
  • ICS-1100 RFIC
• Nuclear magnetic resonance spectroscopy:
  • Spinsolve 80 ULTRA Multi X with autosampler
  • Spinsolve 80 ULTRA Carbon as mobile NMR platform for inline analysis
• UV-Vis:
  • Lambda 1015
  • AVASPEC ULS2048CL for inline analysis
• Infrared spectroscopy:
  • React IR 15 for inline analysis
  • Magna-IR 750

Continuous Flow Chemistry

T. H. Rehm, C. Berguerand, S. Ek, R. Zapf, P. Löb, L. Nikoshvili, L. Kiwi-Minsker
Continuously operated falling film microreactor for selective hydrogenation of carbon-carbon triple bonds.
Chem. Eng. J., 2016, 293, 345

T. H. Rehm, D. Reinhard, H.-J. Kost, C. Hofmann, R. Zapf, P. Löb, Y. Laribi, P. Perrichon, C. Berguerand, L. Kiwi-Minsker, E. Sulman, G. Szirbik, H. Richert, J. Lang, M. Gottfried, S. Roggan
Chemoselective three-phase hydrogenation of an Ombrabulin nitro-stilbene intermediate in a continuous-flow mobile platform.
Chem. Eng. J., 2017, 316, 1069

E. Cermjani, C. Deckers, M. Maskos, T. H. Rehm
Selective decarboxylative fluorination of β-keto acids in aqueous media: 19F-NMR-assisted batch optimization and transfer to continuous flow.
Chem. Eur. J., 2024, 31, e202404435

E. Cermjani, G. Nölke, S. Di Fiore, C. Deckers, D. Hanselmann, B. Herbig, S. Wintzheimer, T. H. Rehm
Two-Step Synthesis of a Chiral Fluorinated Alcohol With Silica-Supported Enzyme RrADH in Batch and Continuous Flow Mode
Chem. Eur. J., 2026, 33, e202503304

Photochemistry

T. H. Rehm, S. Gros, P. Löb, A. Renken
Photonic contacting of gas-liquid phases in a falling film microreactor for photocatalysis with visible light.
React. Chem. Eng., 2016, 1, 636

D. Fabry, Y. A. Ho, R. Zapf, W. Tremel, M. Panthöfer, M. Rueping, T. H. Rehm
Blue light mediated C-H arylation of heteroarenes with TiO₂ as immobilized photocatalyst in a continuous-flow microreactor.
Green Chem., 2017, 19, 1911

C. Deckers, T. H. Rehm
In situ diazonium salt formation and photochemical aryl-aryl coupling in continuous flow monitored by inline NMR spectroscopy
Chem. Eur. J., 2024, e202303692

B. Herbig, E. Cermjani, D. Hanselmann, A. Schmitt, C. Deckers, T. H. Rehm, K. Mandel, S. Wintzheimer
Hydrogen peroxide producing titania-silica supraparticles as tailored photocatalysts for flow chemistry reactions in microfluidic reactors.
Chem Bio Eng., 2025, 2, 199

B. Herbig, E. Cermjani, D. Hanselmann, J. Prieschl, A. Schmitt, M. Moritz, C. Papp, G. Nölke, S. Di Fiore, C. Deckers, T. H. Rehm, S. Wintzheimer
Supraparticles Composed of Graphitic Carbon Nitride Nanoparticles and Silica-Supported Horseradish Peroxidase as Customizable Hybrid Catalysts for Photo-Biocatalytic Cascade Reactions in Continuous Flow
Adv. Funct. Mater., 2025, 2, e202513695

Electroorganic synthesis

A. Ziogas, C. Hofmann, S. Baranyai, P. Löb, G. Kolb
Novel Flexible Electrochemical Microreactor and its Validation by Three Model Electrosyntheses.
CIT, 2020, 92, 513

A. Ziogas, J. Belda, H.-J. Kost, J. Magomajew, R. Sperling, P. Wernig
Peroxodicarbonate: Electrosynthesis and first directions to green industrial applications.
Curr. Res. Green Sustain. Chem. 2022, 5, 2666.

N. Baumgarten, B. Etzold, P. Löb, J. Magomajew, A. Ziogas
Continuous Kolbe Electrolysis Using an Electrochemical Microreactor, Product Separation, and Electrolyte Recycling.
CIT, 2024, 96, 789

J.  Fabarius, C. Pietzka, D. Pangotra, B. Wriedt, L. Vieira, C. Sagstetter, M. Speck, A. Ziogas, N. Baumgarten, H.-J. Kost, P. Löb, K. Patzsch, C. Bernau, S. Boeringer, D. Pico, A. Lieske, M. Vater, U. Wendler, A. Roth
Process Cascade for the Production of Green Polymers from CO₂ and Electric Energy.
CIT, 2024, 96, 698

D. Nater. R. Zhao, J. Rocker, C. Boche, D. Yun, B. Werner, P. Löb, A. Ziogas, S. Waldvogel
Hectogram-Scale Synthesis of Carbamates Using Electrochemical Hofmann Rearrangement in Flow
Org. Process Res. Dev., 2025, 29, 2370

Miscellaneous

T. H. Rehm
Photochemistry in flow for drug discovery.
in Flow chemistry in drug discovery; Eds: J. Alcázar, A. de la Hoz Ayuso, Á. Díaz Ortiz; Springer, Berlin, Heidelberg, 2021

T. H. Rehm, U. Scholz
Durchflusschemie eröffnet neue Wege.
CHEManager, 2023, 5, 10

T. H. Rehm, E. Cermjani, M. Müller, G. Nölke, S. Di Fiore, B. Herbig
Kaskadenreaktionen für die Photobiokatalyse
Tech4Pharma, 2025, 15, 228