Benchtop NMR - Technology for Process Monitoring

From large and ultra-cold to small and convenient

Nuclear magnetic resonance spectroscopy is one fundamental analytical tool for the structure elucidation of chemical compounds and biochemical systems. Recent developments in magnet and NMR technology have made available high-performance spectrometers with ultimate Larmor frequencies higher than 1 GHz. In parallel, however, acquisition costs and maintenance costs grew exponentially according to the available magnet field strength. Hence, both the costs and the sensitivity of these devices did not allow a meaningful application of NMR spectroscopy in an industrial environment until recently. Roughly 10 years ago so-called medium performance benchtop NMR spectrometers entered the market as a low-cost alternative, at first for educational applications at universities only. Permanent magnets substitute the cryogenic components in high performance spectrometers and thus reduce costs in acquisition and maintenance to a fractional amount.

"We use benchtop NMR technology as small-sized, yet powerful analytical tool for continuous flow applications in the chemical industry."

Medium performance NMR spectrometers are commercially available with a magnet configuration that allows Lamor frequencies up to 80 MHz for 1H NMR analysis. Meanwhile 2D NMR analysis can be done as well, e.g. COSY, HSQC and DOSY. Importantly, various NMR-active nuclei can be analyzed and allow a detailed structure elucidation of chemical compounds.

Offer to our customer

Based on our experience in fluidity control and chemical process analysis we adapt benchtop NMR technology as analytical tool to your chemical process. Beside flow cell development and alignment of the spectrometer to your chemical plant we also develop the necessary software for a convenient and easy-to-use interface between the spectrometer, your plant and your staff.

Contactless NMR analysis can be applied as continuous online mode or as by-passed stopped-flow mode to allow longer analysis times during process development. Currently, fluorine (19F), phosphorous (31P) and lithium (7Li) as well as proton (1H) NMR spectroscopy is available for analysis in flow. Deuterated solvents, as usually applied in NMR spectroscopy, are not required.

Whether you are interested in advancing your analytical portfolio or you are thinking about using NMR technology in your processes for the first time, we are the right partner. And of course, if you initially need help in transferring your chemical processes to continuous flow mode we definitely can provide a suitable solution for you based on our long-standing expertise in microreaction technology and continuous flow chemistry.