Fraunhofer Institute for Microengineering and Microsystems IMM
Fraunhofer Institute for Microengineering and Microsystems IMM

Benchtop NMR for process monitoring in continuous-flow chemistry

Bring NMR analysis right where it’s needed: directly to your process—without cryogenics, without massive investments.

© pexels

Benchtop NMR spectroscopy as an online process analytical technique for chemical processes

Fraunhofer IMM develops benchtop NMR solutions for process monitoring in continuous-flow synthesis. We integrate flow cells, spectrometers, and software into your synthesis setup, enabling online and stopped-flow analysis of 1H, 19F, 31P, and 7Li.

 

This offering is aimed at companies that want to monitor, optimize, or convert chemical reactions into continuous processes—using a compact, cost-effective NMR analysis tool directly within the process environment.

 

 

Medium-pressure flow cell for benchtop NMR process analytics
© Fraunhofer IMM
Medium-pressure flow cell for benchtop NMR process analytics

Applications

  • Real-time monitoring of chemical reactions (continuous flow)
  • Process monitoring in stopped-flow or bypass mode
  • Analysis of various industrially relevant nuclei, such as 1H, 19F, 31P, and 7Li
  • Integration into continuously operated production and synthesis plants

 

Advantages

  • Compact, cost-effective alternative to high-field NMR systems
  • No cryogenic components required (lower costs and reduced maintenance)
  • Contactless analysis possible in online and stopped-flow modes
  • No deuterated solvents required
  • Flexible adaptation to different synthesis processes and systems

 

Customer Benefits

  • Improved process control through continuous measurement data acquisition
  • Faster development and optimization of chemical processes
  • Expansion of the company’s analytical portfolio
  • Easier integration of NMR technology into industrial workflows
  • Support for the transition to continuous production (flow chemistry)

Our Services

  • Adaptation of benchtop NMR technology to meet specific customer needs
  • Development of flow cells and their integration into benchtop NMR spectrometers and customer systems
  • Consulting on the implementation and use of NMR spectroscopy in process analytics
  • Support for the transition of batch processes to continuous operation