Nanoparticle-based platform for health solutions for the future

At Fraunhofer IMM, we are revolutionizing the pharmaceutical and biotechnology landscape with our cutting-edge nanomedicine solutions. We have developed a platform that offers the opportunity to manufacture high quality nanomaterials with tunable product characteristics and quantities from milliliter up to decaliter. We are thus accelerating the successful implementation of innovative nanomedical solutions in extensive preclinical trials.

Our approach is based on a highly reliable, flexible and easily scalable modular platform for the continuous synthesis, purification and analysis of nanoformulations, using well-proven microreactor technology. The platform includes a controlled mixing unit, downstream processing (via tangential flow filtration), in-line analytics (via flow dynamic light scattering) and a process control system. Efficient mixing, accurately adjustable residence time and reaction parameters, such as temperature and flow rate are implemented as basic conditions for a reproducible production.

Through our innovative platform, our versatile nanoparticle systems offer a breakthrough approach for therapeutic and diagnostic applications paving the way for clinically relevant nanomedicine applications.

Offer to our customers

Research & Development Services

  • Scalable mRNA formulation system for screening and process development
  • Process development for continuous manufacturing of micromixer assisted nanocarriers
  • Versatile nanoparticle systems for therapeutic and diagnostic applications
  • Optimization and implementation of (inline) nano- and bioanalytics


Core Competencies

  • Formulations (polymer / lipid nanoparticles, liposomes /lipoplexes and niosomes / polymersomes etc.)
  • Hybrid extracellular vesicle technology
  • Downstream processing for nanoformulations
  • Magnetic Particle Imaging (MPI)
  • Hyperthermia (Magnetic Fluid Hyperthermia)




1. NEXTGENMEDINKUBATOR (The modular biolab in a container)

In collaboration with the EFRE-REACT program, we are driving innovation through miniaturizing and automating process steps, to enhance integration capability in complex process sequences and enable the seamless transition to container-based concepts. Our modular biolab in a container offers flexible solutions for biotechnology start-ups, facilitating faster implementation of biotechnological processes.

2. RNAuto (Automated production technologies of mRNA-derived vaccines and gene and cell therapeutics)

Globally, the lack of GMP-compliant manufacturing sites and mature production technologies for innovative nanodrugs and cell therapeutics, poses major challenges to the healthcare system. However, barriers need to be broken down to extend the usage of mRNA-based vaccines for future pathogens and boost the application of mRNA-based tools for individual medicine such as gene and cell therapy. We aim at developing automated and digitally supported production technologies for faster, safer and reliable processes for mRNA-based nanomedicines meeting pharmaceutical manufacturing standards.

3. BioTherNa (Biomimetic thermoresponsive nanomaterials for more effective cancer therapies)

Tumor cells commonly have an increased temperature of around 1-2°C compared to surrounding tissue. By packing  hazardous active substances into envelopes that can be opened using a special switch of tumor cells we are able to specifically transport these cancer drugs to their target. The envelopes are made from a temperature-controllable material inspired from a biomimetic concept modelled on a completely natural process of the double helix of DNA strands. This approach should become more compatible with conventional chemotherapy with targeted and controlled release.

4. KIWI - SPORT: Speciality lipids and process technology for optimized RNA therapeutics

The BMWK sponsored consortium is focused on improving the production capacities as well as R&D of specialty lipids and other excipients for mRNA-based medicines. We particularly contribute the knowhow in formulation technology and special nanoanalytics to develop microtechnology based formulations. This also includes production of novel lipid and polymer-based transport systems in a scalable manner for mRNA delivery.

5. SFB 1552: Defects and Defect Engineering in Soft Matter

The utilisation of "defects" is, for example, of crucial importance for the func-tion of semiconductors or the properties of mechanical components. In con-trast, the effects of such defects have hardly been researched in the colloid sciences. In an interdisciplinary DFG Collaborative Research Centre, we are working on this issue together with the Johannes Gutenberg University Mainz and the Max Planck Institute for Polymer Research. Our aim is to introduce various nanoscale colloids as defects in membranes, to influence and under-stand their properties and effects, and to use them in a targeted way.


Project Partners

  • BioNTech SE
  • University of Leipzig
  • Johannes Gutenberg University Mainz
  • Lipoid GmbH
  • Fraunhofer IZI-BB
  • nanoPET Pharma GmbH
  • Institute for Translational Immunology (TIM)
  • Physikalisch-Technische Bundesanstalt


Thermorepsonsive Nanocarrier”:
Mixture, aqueous solution containing the mixture, and uses of the aqueous solution. DE Patent, WO Patent Application, Priority 01.03.2022

Microfluidic Liposome Production”:
Method and device for producing a liquid containing liposomes, and produced liquid, DE, EP, CN, IL and US Patent Applications, 19.11.2019

Dynamic Light Scattering on Flowing Dispersions”:
Method for determining the average particle size of particles which are suspended in a liquid and flowing medium, by means of dynamic light scattering, and a device therefore. DE, EP, CN and US-Patent, 04.07.2016

Single-Core, magnetic iron oxide Nanoparticles”:
Method for producing stable dispersible magnetic iron oxide single-core Nanoparticles, stable dispersible magnetic iron oxide single-core nanoparticles and uses of same. EP, US and CN Patent, 18.08.2015


At Fraunhofer IMM’s Nanomedicine Group, we're not just envisioning the future of medicine; we're making it a reality!


Join us in shaping the future of healthcare through innovative nanomedicine solutions. For inquiries and collaborations, please contact us.

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Career and Training

We invite you to share your interest in joining our team. We also offer exclusive training for both academic and industrial personnel. Gain hands-on experience with our cutting-edge technology tailored to your needs and contribute to building a skilled workforce for a sustainable future.

Reach out to us to explore career opportunities and training programs.