In-situ production of Grignard reagents with continuous process control
Since its discovery more than 100 years ago, the synthesis of Grignard reagents and their conversion with a variety of organic molecules such as ketones and aldehydes has been one of the most effective methods of C-C bond formation. In the synthesis of the top 50 active pharmaceutical ingredients, in about 10 percent of the synthetic pathways one Grignard reaction or more can be found.
„We enable your chemistry to develop its full potential”
The actual Grignard reagent formation represents a reaction that can immensely benefit from a continuous process. This is mainly due to the following aspects:
- Novel Process Window - large magnesium excess to suppress unwanted side reactions such as Wurtz coupling,
- improved heat transfer, no runaway of the reaction,
- continuous supply of magnesium,
- integrated magnesium activation,
- integrated process control,
- inline analytics via IR measurements.